| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373215 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.
Graphical abstractVitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.Figure optionsDownload full-size imageDownload as PowerPoint slide
