| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373217 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure–activity relationships (SAR) of the series are described.
Graphical abstractThe synthesis and biological activity of a series of aminotetralin-derived heteroaryl urea TRPV1 antagonists is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michele C. Jetter, Mark A. Youngman, James J. McNally, Mark E. McDonnell, Sui-Po Zhang, Adrienne E. Dubin, Nadia Nasser, Ellen E. Codd, Christopher M. Flores, Scott L. Dax,