| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373218 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.
Graphical abstractMevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yongge Qiu, Jinbo Gao, Fei Guo, Yuqin Qiao, Ding Li,