| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373220 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of benzazepinones were synthesized and evaluated as hNav1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.
Graphical abstractA series of benzazepinones were synthesized and evaluated as hNav1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Scott B. Hoyt, Clare London, Hyun Ok, Edward Gonzalez, Joseph L. Duffy, Catherine Abbadie, Brian Dean, John P. Felix, Maria L. Garcia, Nina Jochnowitz, Bindhu V. Karanam, Xiaohua Li, Kathryn A. Lyons, Erin McGowan, D. Euan MacIntyre, William J. Martin,