| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373230 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
Graphical abstractProperly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in mouse A2780 xenograft model.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Kamil Paruch, Michael P. Dwyer, Carmen Alvarez, Courtney Brown, Tin-Yau Chan, Ronald J. Doll, Kerry Keertikar, Chad Knutson, Brian McKittrick, Jocelyn Rivera, Randall Rossman, Greg Tucker, Thierry O. Fischmann, Alan Hruza, Vincent Madison,