| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373231 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Based on a pharmacophore alignment on a 5-HT6 ligand applying 4SCan® technology, a new lead series was identified and further structurally investigated. Kis down to 8 nM were achieved.
Graphical abstractThe discovery and SAR studies of 5-HT6 ligands are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefan Tasler, Jürgen Kraus, Andreas Wuzik, Oliver Müller, Andrea Aschenbrenner, Elena Cubero, Rosalia Pascual, Jordi-Ramon Quintana-Ruiz, Alberto Dordal, Ramon Mercè, Xavier Codony,