| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373236 | Bioorganic & Medicinal Chemistry Letters | 2007 | 7 Pages |
Abstract
Low nanomolar corticotropin releasing factor type-1 (CRF1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a Ki = 11 ± 1 nM. The oxygen-linked pyrazinyl derivatives were prepared through a copper-catalyzed coupling of a pyridinone to a bromo- or iodopyrazine.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey W. Corbett, Mark R. Rauckhorst, Fang Qian, Robert L. Hoffman, Christopher S. Knauer, Lawrence W. Fitzgerald,