Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373237 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A novel series of potent substituted anilinoquinolines were discovered as c-fms inhibitors. The potency could be manipulated upon modification of the C4 aniline and C7 aryl functionality. Pharmacokinetic analysis identified a metabolically stable analog suitable for further investigative work.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Terrence L. Smalley Jr., Stanley D. Chamberlain, Wendy Y. Mills, David L. Musso, Sab A. Randhawa, John A. Ray, Vicente Samano, Lloyd Frick,