| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373255 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A novel class of 3-phenyl-2-styryl-3H-quinazolin-4-one Hsp90 inhibitors with in vitro anti-tumor activity is identified by structure-based virtual screening of a chemical database with docking simulations in the N-terminal ATP-binding site, in vitro ATPase assay using yeast Hsp90, and cell-based Her2 degradation assay in a consecutive fashion.
Related Topics
Physical Sciences and Engineering
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Authors
Hwangseo Park, Yun-Jung Kim, Ji-Sook Hahn,