Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373281 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of nitrogen-containing polyhydroxylated aromatics from caffeic acid phenethyl ester were designed and synthesized as HIV-1 integrase inhibitors. Most of these compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in the 3′-end processing and the strand transfer. Their key structure–activity relationship was also discussed.
Graphical abstractA series of novel nitrogen-containing polyhydroxylated aromatics were evaluated for their ability to inhibit HIV-1 integrase at micromolar concentrations.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peng Wang, Chuan Liu, Tino Sanches, Yuan Zhong, Bo Liu, Junlong Xiong, Nouri Neamati, Guisen Zhao,