| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373284 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of imidazo[1,2-a]pyridine derivatives was identified and evaluated for MCH1R binding and antagonistic activity. Introduction of a methyl substituent at the 3-position of imidazo[1,2-a]pyridine provided compounds with a significant improvement in MCH1R affinity. Representative compounds in this series exhibited good potency and brain exposure in rats.
Graphical abstractThe synthesis and evaluation of a series of imidazo[1,2-a]pyridine derivatives as MCH1R antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Hiroyuki Kishino, Minoru Moriya, Shunji Sakuraba, Toshihiro Sakamoto, Hidekazu Takahashi, Takao Suzuki, Ryuichi Moriya, Masahiko Ito, Hisashi Iwaasa, Norihiro Takenaga, Akane Ishihara, Akio Kanatani, Nagaaki Sato, Takehiro Fukami,