| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373295 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.
Graphical abstractCYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christopher J. Burns, Michael F. Harte, Xianyong Bu, Emmanuelle Fantino, Max Joffe, Harrison Sikanyika, Stephen Su, C. Elisabet Tranberg, Neil Wilson, Susan A. Charman, David M. Shackleford, Andrew F. Wilks,