| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373300 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In addition, these compounds had improved selectivity against hERG channel inhibition.
Graphical abstractWe have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In addition, these compounds had improved selectivity against hERG channel inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide
