| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373304 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Chemical investigation of Ulmus wallichiana stem bark resulted in isolation and identification of three new compounds (2S,3S)-(+)-3′,4′,5,7-tetrahydroxydihydroflavonol-6-C-β-d-glucopyranoside (1), (2S,3S)-(+)-4′,5,7-trihydroxydihydroflavonol-6-C-β-d-glucopyranoside (3) and 3-C-β-d-glucopyranoside-2,4,6-trihydroxymethylbenzoate (8), together with five known flavonoid-6-C-glucosides (2, 4–7). Their structures were elucidated using 1D and 2D NMR spectroscopic analysis. The absolute stereochemistry in compounds 1 and 3 were established with the help of CD data analysis and comparison with the literature data analysis. All the isolated compounds (1–8) were assessed for promoting the osteoblast differentiation using primary culture of rat osteoblast as an in vitro system. Compounds 1–3 and 5 significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity.
Graphical abstractThree new compounds, ulmoside A (1) ulmoside B (3) and ulmoside C (8) along with five known compounds were isolated from Ulmus wallichiana. Compounds 1-3 and 5 showed promising osteogenic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
