| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373310 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. The most potent inhibitor exhibited a BACE-1 IC50 value of 0.23 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fredrik Wångsell, Francesco Russo, Jonas Sävmarker, Åsa Rosenquist, Bertil Samuelsson, Mats Larhed,