Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373315 | Bioorganic & Medicinal Chemistry Letters | 2009 | 7 Pages |
Abstract
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.
Graphical abstractTwo series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, Richard D. Caldwell, Justin A. Caravella, Lihong Chen, Katrina L. Creech, David N. Deaton, Kevin P. Madauss, Harry B. Marr, Robert B. McFadyen, Aaron B. Miller, Frank Navas III, Derek J. Parks, Paul K. Spearing,