Article ID Journal Published Year Pages File Type
1373323 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract

Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized and tested for their ability to activate the niacin receptor. One analog, 23, showed improved potency and lacked flushing at doses that effectively altered the lipid profile of rats.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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