| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373329 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat.
Graphical abstractHigh throughput screening identified a 7-azaindole-3-acetic acid scaffold 7 as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound 13l with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
David A. Sandham, Claire Adcock, Kamlesh Bala, Lucy Barker, Zarin Brown, Gerald Dubois, David Budd, Brian Cox, Robin A. Fairhurst, Markus Furegati, Catherine Leblanc, Jodie Manini, Rachael Profit, John Reilly, Rowan Stringer, Alfred Schmidt,