| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373337 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of arylsulfonamides containing guanidine incorporated in the structure of secondary amines (piperidine, piperazine) was synthesized on SynPhase Lanterns and evaluated for 5-HT1A, 5-HT2A, and 5-HT7 receptors. The results demonstrated that N-alkyl-N′-dialkylguanidines displayed good 5-HT7/5-HT1A selectivity and may be regarded as promising structural core for development of 5-HT7 ligands.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paweł Zajdel, Gilles Subra, Pascal Verdie, Ewa Gabzdyl, Andrzej J. Bojarski, Beata Duszyńska, Jean Martinez, Maciej Pawłowski,