Article ID Journal Published Year Pages File Type
1373343 Bioorganic & Medicinal Chemistry Letters 2009 6 Pages PDF
Abstract

We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of tumor cells by the fluorescent acetazolamide derivative and the ability of the albumin-binding acetazolamide derivative to cause tumor retardation in a SK-RC-52 xenograft model of cancer.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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