Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373343 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of tumor cells by the fluorescent acetazolamide derivative and the ability of the albumin-binding acetazolamide derivative to cause tumor retardation in a SK-RC-52 xenograft model of cancer.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Julia K.J. Ahlskog, Christoph E. Dumelin, Sabrina Trüssel, Jessica Mårlind, Dario Neri,