| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373348 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Identification of potent benzothiophene inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2), structure–activity relationship (SAR) studies, selectivity assessments against CDK2, cellular potency and mechanism of action are presented. Crystallographic data provide a rationale for the observed MK2 potency as well as selectivity over CDK2 for this class of inhibitors.
Graphical abstractThe synthesis of a novel class of MK2 inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David R. Anderson, Marvin J. Meyers, Ravi G. Kurumbail, Nicole Caspers, Gennadiy I. Poda, Scott A. Long, Betsy S. Pierce, Matthew W. Mahoney, Robert J. Mourey,