Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373365 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A novel epoxide 2 was formed as the major product in the reaction of 2-bromo-3-methyl-1,4-naphthoquinone with 1,3-propanedithiol in the presence of triethylamine in 92% yield. Molecular oxygen is suggested to be the source of the added oxygen in 2, an oxidation product of its precursor 3. A strong base such as triethylamine is required to abstract the methyl hydrogen of 1,4-naphthoquinones, leading to the formation of 3 as well as 2.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tom M. Lam, Chain Lee, Katherine Katardjieff, Tetsuo Otsuki,