| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373366 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A new series of 1-methyl-1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. Some of the analogues in this series displayed inhibitory activity superior to lamivudine. Of them, compound 13b was the most potent one, showing an IC50 value of 7.8 μM and a SI value of 13.0.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yanfang Zhao, Yajing Liu, Dong Chen, Zengquan Wei, Wenzhao Liu, Ping Gong,