| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373367 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Optimization from compound 4a, having intramolecular S–O nonbonded interaction, led to discover compounds 4m and 4n. They were highly active in vitro (VEGF induced HUVEC proliferation assay) and showed efficacies in three disease models in vivo (cancer, RA, AMD).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hisashi Tajima, Takahiro Honda, Kenji Kawashima, Yoshimasa Sasabuchi, Minoru Yamamoto, Masakazu Ban, Kazuyoshi Okamoto, Kenji Inoue, Takaaki Inaba, Yuriko Takeno, Hiroyuki Aono,