| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373374 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Appropriately designed 2′-N-(pyren-1-yl)carbonyl-2′-amino-LNA (locked nucleic acid) display large increases in fluorescence intensity and remarkably high quantum yields upon hybridization with nucleic acid targets. Thermal denaturation and fluorescence spectroscopy studies on ONs modified with known thymine monomer X and novel 5-methylcytosine monomer Y provide new insights into the design principles and mechanism of these Glowing LNA nucleic acid detection probes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael E. Østergaard, Jyotirmoy Maity, B. Ravindra Babu, Jesper Wengel, Patrick J. Hrdlicka,