| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373378 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (Ki) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vinay M. Girijavallabhan, Lei Chen, Chaoyang Dai, Robert J. Feltz, Luke Firmansjah, Dansu Li, Seong Heon Kim, Joseph A. Kozlowski, Brian J. Lavey, Aneta Kosinski, John J. Piwinski, Janeta Popovici-Muller, Razia Rizvi, Kristin E. Rosner,