| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373385 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven drugs had solubility <10 μM. Using these data, we established a solubility criterion to support CNS discovery. The implication of poor solubility with potential safety concerns and undesirable side effects are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yun W. Alelyunas, James R. Empfield, Dennis McCarthy, Russell C. Spreen, Khanh Bui, Luciana Pelosi-Kilby, Cindy Shen,