Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373390 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Targeted drug deliveries as well as high resolution imaging of cancerous tissues and organs via specific cancer cell markers have become important in chemotherapeutic interventions of cancer treatment. Short peptides such as RGD and NGR are showing promising results for targeted drug delivery and in vivo imaging. We have applied on resin Huisgen’s 1,3-dipolar cycloaddition to synthesize new cyclic RGD and NGR peptide analogs. Preliminary binding assays of these new analogs by fluorescence polarization indicates specific binding to purified CD13 (Aminopeptidase N) and cell lysates from MCF-7 and SKOV-3 cancer cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Belhu B. Metaferia, Matthew Rittler, Jinesh S. Gheeya, Albert Lee, Heidi Hempel, Alberto Plaza, William G. Stetler-Stevenson, Carole A. Bewley, Javed Khan,