| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373391 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.
Graphical abstractThe optimisation of diamide 1 to amine 2, a soluble and selective NPY Y2 receptor antagonist with enhanced CNS exposure is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gillian E. Lunniss, Ashley A. Barnes, Nick Barton, Matteo Biagetti, Federica Bianchi, Stephen M. Blowers, Laura L. Caberlotto, Amanda Emmons, Ian P. Holmes, Dino Montanari, Roz Norris, Gemma V. Puckey, Dewi J. Walters, Steve P. Watson, John Willis,