Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373392 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic acid-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin ανβ3 receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.
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Chemistry
Organic Chemistry
Authors
Arsénio de Sá, Áurea A. Matias, M. Isabel M. Prata, Carlos F.G.C. Geraldes, P.M.T. Ferreira, João P. André,