| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373397 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide–alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.
Graphical abstractA series of triazoloacyclic nucleoside phosphonates were synthesized and evaluated for their in vitro antiviral activities (HCV and HIV) and cytotoxicities.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hanane Elayadi, Michael Smietana, Christophe Pannecouque, Pieter Leyssen, Johan Neyts, Jean-Jacques Vasseur, Hassan B. Lazrek,