| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373404 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The iron-ion catalyzed oxidation of the ethanol solution of rosmarinic acid, a potent antioxidant polyphenol of Lamiaceae (Labiatae) plants, afforded a highly tyrosinase-inhibitory active product. The structure of the active product in the oxidation product mixture was determined using extensive NMR spectroscopy to have a novel oxygen-containing seven-membered ring system. The formation mechanism of the unique ring structure from the catechol part of the rosmarinic acid was proposed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aya Fujimoto, Yoshimi Shingai, Mitsuhiro Nakamura, Tomomi Maekawa, Yoshiaki Sone, Toshiya Masuda,