| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373405 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Several series of carbamate, urea and carboxamide-based CCR5 antagonists have been discovered via optimizations at the amine portion of lead compound 2. All compounds were evaluated for their antiviral activities. Lead urea 29 showed good pharmacokinetic properties, justifying further development of this series.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maosheng Duan, Jennifer Peckham, Mark Edelstein, Robert Ferris, Wieslaw M. Kazmierski, Andrew Spaltenstein, Pat Wheelan, Zhiping Xiong,