Article ID Journal Published Year Pages File Type
1373406 Bioorganic & Medicinal Chemistry Letters 2010 4 Pages PDF
Abstract

Modification of the acyl moiety in the CCR5 lead molecule 2 led to identification of several new classes of CCR5 antagonists. Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated. Structure–activity relationship (SAR) derived from these studies further guided the optimization efforts, ultimately leading to the discovery of 36 with an acceptable drug-like profile.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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