Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373406 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Modification of the acyl moiety in the CCR5 lead molecule 2 led to identification of several new classes of CCR5 antagonists. Antiviral activity and pharmacokinetic properties of the synthesized compounds were evaluated. Structure–activity relationship (SAR) derived from these studies further guided the optimization efforts, ultimately leading to the discovery of 36 with an acceptable drug-like profile.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maosheng Duan, Jennifer Peckham, Mark Edelstein, Robert Ferris, Wieslaw M. Kazmierski, Andrew Spaltenstein, Pat Wheelan, Zhiping Xiong,