Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373407 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Two cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives were synthesized as antioxidants against light-induced retinal degeneration. Whereas nitrone 10 significantly protected retina against bright fluorescent light exposure when injected into the vitreous at 1 mM, no protection was observed with nitrone 6. The parent compound α-phenyl-N-tert-butyl nitrone also exhibited protective activity at 9 mM but not at 1 mM. This suggests that nitrone 10 may be a candidate for the treatment of retinal diseases.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fanny Choteau, Grégory Durand, Isabelle Ranchon-Cole, Christine Cercy, Bernard Pucci,