| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373410 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
This paper describes the discovery and design of a novel class of JAK2 inhibitors. Furthermore, we detail the optimization of a screening hit using ligand binding efficiency and log D. These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tony Siu, Ekaterina S. Kozina, Joon Jung, Craig Rosenstein, Anjili Mathur, Michael D. Altman, Grace Chan, Lin Xu, Eric Bachman, Jan-Rung Mo, Melaney Bouthillette, Thomas Rush, Christopher J. Dinsmore, C. Gary Marshall, Jonathan R. Young,