Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373414 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The strategy and SAR studies that led to the discovery of a novel potent and orally available 5-lipoxygenase (5-LO) inhibitor 3-(4-fluorophenyl)-6-({4-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1H-1,2,3-triazol-1-yl}methyl)-1-benzothiophene-2-carboxamide ((S)-2l or MK-5286) were described.
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Related Topics
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Authors
Lianhai Li, Carl Berthelette, Anne Chateauneuf, Marc Ouellet, Claudio F. Sturino, Zhaoyin Wang,