Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373424 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The design, synthesis and calcimimetic properties of various cyclic sulfonamides and sulfamates are described. The latter were prepared from the corresponding o-alkenylarenesulfonamides via copper- or rhodium-catalyzed intramolecular aziridination. The size of the cyclic sulfonamide rings as well as the position of the crucial (R)-naphthylethylamine substituent significantly affected calcimimetic activity. The most active compounds were the six- and seven-membered sulfonamides 30a and 31a and sulfamate 34a.
Graphical abstractCyclic sulfonamides and sulfamates as new calcimimetic agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lionel Kiefer, Tatiana Gorojankina, Philippe Dauban, Hélène Faure, Martial Ruat, Robert H. Dodd,