| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373425 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christos I. Stathakis, Ioannis Mavridis, Georgia Kythreoti, Athanasios Papakyriakou, Ioannis A. Katsoulis, Thomas Cottin, Panoula Anastasopoulou, Dionisios Vourloumis,