| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373431 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The synthesis and in vitro binding affinity for a novel series of potent androgen receptor modulators is described. One of the more potent compounds (17, RAD35010) was further characterized in vivo where it restored levator ani weight in castrated male rats to near sham level while having no significant effect on prostate weight.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chris P. Miller, Pushpal Bhaket, Nagarajan Muthukaman, C. Richard Lyttle, Maysoun Shomali, Kyla Gallacher, Connie Slocum, Gary Hattersley,