SAR studies of gymnasterkoreayne derivatives with cancer chemopreventive activities

We synthesized diyne triols based on gymnasterkoreayne and evaluated their cancer chemopreventive activities in terms of the chemopreventive index (CI) to reveal the structure–activity relationship, and discovered more active compounds than natural diynes.

Graphical abstractWe synthesized diyne triols, derivatives of gymnasterkoreayne and evaluated their cancer chemopreventive activities by chemopreventive index (CI) to reveal structure–activity relationship, and discovered more active compounds than natural diynes.Figure optionsDownload full-size imageDownload as PowerPoint slide