| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373452 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Koji Matsuoka, Chiharu Takita, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I.P.J. Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Ken Hatano, Daiyo Terunuma,