Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373455 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A new class of non-nucleoside antivirals is reported, wherein a C-3 methyl group confers dramatic improvement in potency, perhaps due to conformational restriction of the C-2 sidechain.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Larsen, Zhijun Zhang, Brian A. DiPaolo, Peter R. Manninen, Douglas C. Rohrer, Michael J. Hageman, Todd A. Hopkins, Mary L. Knechtel, Nancee L. Oien, Bob D. Rush, Francis J. Schwende, Kevin J. Stefanski, Janet L. Wieber, Karen F. Wilkinson,