| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373455 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A new class of non-nucleoside antivirals is reported, wherein a C-3 methyl group confers dramatic improvement in potency, perhaps due to conformational restriction of the C-2 sidechain.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase](/preview/png/1373455.png "First Page Preview: 7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase")
Authors
Scott D. Larsen, Zhijun Zhang, Brian A. DiPaolo, Peter R. Manninen, Douglas C. Rohrer, Michael J. Hageman, Todd A. Hopkins, Mary L. Knechtel, Nancee L. Oien, Bob D. Rush, Francis J. Schwende, Kevin J. Stefanski, Janet L. Wieber, Karen F. Wilkinson,