| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373460 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of 3-arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides were prepared and shown to be novel and selective antagonists of the CXCR2 receptor. Synthesis, structure and activity relationships, selectivity, and some developability properties are described.
Graphical abstractSynthesis, structure and activity relationships, selectivity and developability properties for a new class of CXCR2 receptor antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yonghui Wang, Jakob Busch-Petersen, Feng Wang, Lanping Ma, Wei Fu, Jeffrey K. Kerns, Jian Jin, Michael R. Palovich, Jing-Kang Shen, Miriam Burman, James J. Foley, Dulcie B. Schmidt, Gerald E. Hunsberger, Henry M. Sarau, Katherine L. Widdowson,