Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1373462 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
4-Arylpyrano-[3,2-c]-pyridones have been prepared by a one-step cyclocondensation of 4-hydroxy-1,6-dimethylpyridin-2(1H)-one with various substituted benzaldehydes and malononitrile. These heterocycles exhibit micromolar and submicromolar antiproliferative activity in HeLa and induce apoptosis in Jurkat cell lines. Structure–activity studies performed on a small library of these compounds show a pronounced cytotoxicity enhancing effect of the bromo substituent at the meta position of the C4 aromatic moiety.
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Related Topics
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Organic Chemistry
Authors
Igor V. Magedov, Madhuri Manpadi, Nikolai M. Evdokimov, Eerik M. Elias, Elena Rozhkova, Marcia A. Ogasawara, Jennifer D. Bettale, Nikolai M. Przheval’skii, Snezna Rogelj, Alexander Kornienko,