| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373472 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Structure–activity relationships and efforts to optimize the pharmacokinetic profile of a class of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among the compounds examined, compound 14 showed potent affinity and high selectivity for CB2, and compound 23 showed potent affinities against CB1 and CB2. These compounds displayed oral bioavailability.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroyuki Kai, Yasuhide Morioka, Minoru Tomida, Tadashi Takahashi, Maki Hattori, Kohji Hanasaki, Katsumi Koike, Hiroki Chiba, Shunji Shinohara, Toshiyuki Kanemasa, Yuka Iwamoto, Kohji Takahashi, Yoshitaka Yamaguchi, Takahiko Baba, Takayoshi Yoshikawa,