| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373474 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Surface-rigidified cerasomes (ceramic-coated liposomes) are neither fused nor cross-linked when bound to siRNA (short duplex RNA) but not to plasmid DNA (long duplex DNA) which induces cross-linking. Non-ceramic reference liposomes are easily fused by the siRNA. The cerasome can thus be used as a viral-size siRNA-carrier in a wide range of concentration for RNAi silencing of exogenous and endogenous genes.
Graphical abstractCerasome can be used as a viral-size siRNA-carrier for RNAi silencing of exogenous and endogenous genes.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuki Matsui, Yoshihiro Sasaki, Takayoshi Komatsu, Masaru Mukai, Jun-ichi Kikuchi, Yasuhiro Aoyama,