| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373479 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
Graphical abstractNovel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tomomi Noguchi-Yachide, Atsushi Aoyama, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto,