| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373488 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Hypericin monocarboxylic acid was synthesized in an overall yield of 25% in four steps and radiolabelled with iodine-123 in good yield (>75%). The resulting mono-[123I]iodohypericin monocarboxylic acid was evaluated in normal mice and in rats with ethanol induced liver necrosis. In this model, tracer concentration in necrotic liver tissue was 14 times higher than in the viable liver tissue as quantified by autoradiography at 24 h post injection. The results indicate the feasibility of visualization of necrotic tissue with the novel tracer.
Graphical abstractThe study describes the synthesis and preliminary biological evaluation of mono-[123I]iodohypericin monocarboxylic acid as a potential tracer agent for in vivo visualization of necrosis by SPECT.Figure optionsDownload full-size imageDownload as PowerPoint slide
![Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent](/preview/png/1373488.png "First Page Preview: Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent")