| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1373489 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Potent and orally active benzodiazepinone-based γ-secretase inhibitors with a narrow therapeutic range were identified.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's d](/preview/png/1373489.png "First Page Preview: Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): A γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's d")
Authors
C.V.C. Prasad, Ming Zheng, Shikha Vig, Carl Bergstrom, David W. Smith, Qi Gao, Suresh Yeola, Craig T. Polson, Jason A. Corsa, Valerie L. Guss, Alice Loo, Jian Wang, Bogdan G. Sleczka, Charles Dangler, Barbara J. Robertson, Joseph P. Hendrick,